Selective Androgen Receptor Modulators also described as SARMs, are a special class of therapeutic molecules that are created with similar properties of anabolic-androgenic steroids to treat diseases and improve body shape. Some SARMs are proven to be clinically tested. Despite the fact that it produces properties similar to that of AAS, it is selective in action. SARMs produce hypertrophic and anabolic activity in the bone and muscle when bound to the receptor. This makes them suitable for the treatment of osteoporosis, muscle wasting, and TRT (Testosterone Replacement Therapy). It also provides results similar to that of anabolic-androgenic steroids, which include less fat, better bone density, and increased lean muscle mass. The side effects are very few – water retention and estrogen-related effects. It has a high anabolic to androgenic ratio of 10:1. That way they help build an individual’s muscles with little or no side effects. They possess high bioavailability which makes them easy to utilize and absorb.
What Makes SARMs Better Than AAS?
SARMs are more beneficial for human consumption as they are non-toxic to the liver and does not affect blood pressure. This implies that you don’t need to pre-load and use on-cycle support supplements. It is also less expensive to use when compared to steroids or prohormones supplements. Additionally, you need not worry about water retention and estrogen-related effects.
Types Of SARMs
- LGD 4033:
This SARM-like Ostarine has a potency that is 12 times that of SARMs at just one-third level of dosage. Therefore, it is a suppressant to the Hypothalamus-Pituitary-Testes-Axis (HPTA). The HPTA is made up of the hypothalamus, pituitary gland and gonadal gland, and it performs the function of developing and regulating the reproductive and immune systems. It is advised that you use a Selective Estrogen Receptor Modulator (SERM) post cycle therapy once you are done with this dietary supplement.
The Ostarin is used during a cutting cycle. Alongside that, it is a great bulking agent with a half-life range of 24 to 36 hours which makes daily dosage optimal.
This is the most popular SARM in the market. It is known to retain muscle mass while having a deficit in calories. It has the capacity to suppress the natural production of testosterone during higher and longer dosed cycles. Hence, you need to complement it with SERM PCT. Some users may experience gyno, which implies that AIs such as Exemestane is needed. Ostarin has a cycle length ranging from 6 to 8 weeks on an average and a dosage ranging from 10mg to 25mg.
- MK 677 (Ibutamoren):
This SARM is non-peptidic. It mimics the outcome of ghrelin (which is a hormone that controls one’s appetite and the distribution and usage of energy) in the stomach and enhances the IGF-1 levels and growth hormone, without affecting the cortisol levels. Based on several studies, MK 677 is known to enhance bone density and muscle mass. The IGF-1 levels are also increased in humans by 60% in just 6 weeks and 72% after a year. It is non-hormonal and best used in a 3-month cycle at a minimum with increased dosage each month.
- Andarine S4:
This is one of the strongest and potent receptors in the market. It was initially manufactured by GTx Inc (based in Memphis) to treat enlarged prostate – benign prostatic hypertrophy. Although it is not the most effective SARM on paper, several bodybuilders adopted it as a result of its fast positive results on fat loss and muscle mass gain. It helps enhance protein synthesis and initiate anabolic processes in the body. What makes Andarine S4 unique when compared to other SARMs is its selective features. You can be assured an increase in lean muscle mass and fat loss. Also, it helps retain muscle mass during a cut. At low dosages, it can be truly potent.
If you wish to find out more information on these SARMs (most especially the Andarine S4) and how to get them, you can read more into Andarine at HealthEd Academy.